ABSORPTION
Aceclofenac controlled release injection is supplied as intramuscular administration ans should be injected deep intramuscular once a day. A repeated dose at a duration of 12hrs may required in severe pain. There is no evidence that the dosage of Aceclofenac need to be modified in patient with mild renal impairment, but as with other NSAIDs caution should be exercised. The Dose of Aceclofenac should be reduced in patient with hepatic impairment
Adults: The recommended dose of Aceclofenac is 150mg once daily.
Children: There is no Clinical Data on the use of Aceclofenac in children therefore it is not recommended for use in children.
Elderly: The pharmacokinetics of Aceclofenac is not altered in elderly patients, therefore it is not considered necessary to modify the dose and dose frequency.
Renal Insufficiency: There is no evidence that the dosage of Aceclofenac needs to be modified in patients with mild renal impairment.
Hepatic Insufficiency: The dose of Aceclofenac should be reduced in patients with hepatic impairment. An initial daily dose of 150mg should be administered
DRUG INTERACTIONS
Aceclofenac controlled release can increase plasma concentration of lithium, digoxin and methotrexate, increase the activity of anticoagulant, inhibits the activity of diuretics, enhance cyclosporin nephrotoxicity and precipitate convulsions when co-administered with quinolone antibiotics. When administered concomitantly with potassium sparing diuretics (spirinolactone), serum potassium should be monitored. The co administration of Aceclofenac with other NSAIDs or corticosteroids may results in increased frequency of adverse event.
ADVERSE EFFECTS
The Aceclofenac controlled release injection has decreased adverse effects on the GI tract, therefore making more tolerable. Aceclofenac is well tolerated, with minor adverse events. Being minor, it is resolve after discontinuation of therapy.
| ADVERSE EFFECT | ||
|---|---|---|
| TYPE | RANGE | SIDE EFFECT |
| COMMON | Between 1% and 10% | Dizziness, indigestion, nausea, diarrhea, abnormal laboratory test results, ulcers and bleeding |
| UNMMON | Between 0.1% and 1% | Flatulence, constipation,vomiting,itching,skin rash,urticaria,mouth problems |
| RARE | Between 0.01% and 0.1% | Depression, strange dreams,sleeping problems, breathing problems, facial swelling |
| VARY RARE | Less than 0.01% | Depression, strange dreams, sleeping problems,tremors, taste changes, sleepines, palpitation |
